Potential role of genomic imprinted genes and brain developmental related genes in autism
نویسندگان
چکیده
منابع مشابه
Abnormal RNA expression of 11p15 imprinted genes and kidney developmental genes in Wilms' tumor.
Wilms' tumor (WT) is caused by abnormal development of embryonal kidney cells. WT cells are frequently affected by deletions or functional inactivation of maternal alleles at chromosome 11p15, which indicates that the loss of maternally expressed genes in this region plays an important role in WT pathogenesis. Maternally expressed genes indeed exist within an imprinted region at 11p15.5. Among ...
متن کاملKidney Developmental Genes in Wilms' Tumor Abnormal RNA Expression of 11p15 Imprinted Genes and Updated Version
Wilms’ tumor (WT) is caused by abnormal development of embryonal kidney cells. WT cells are frequently affected by deletions or functional inactivation of maternal alleles at chromosome 11p15, which indicates that the loss of maternally expressed genes in this region plays an important role in WT pathogenesis. Maternally expressed genes indeed exist within an imprinted region at 11p15.5. Among ...
متن کاملIdentification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization.
We have identified three C/D-box small nucleolar RNAs (snoRNAs) and one H/ACA-box snoRNA in mouse and human. In mice, all four snoRNAs (MBII-13, MBII-52, MBII-85, and MBI-36) are exclusively expressed in the brain, unlike all other known snoRNAs. Two of the human RNA orthologues (HBII-52 and HBI-36) share this expression pattern, and the remainder, HBII-13 and HBII-85, are prevalently expressed...
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The imprinted brain theory proposes that autism spectrum disorder (ASD) represents a paternal bias in the expression of imprinted genes. This is reflected in a preference for mechanistic cognition and in the corresponding mentalistic deficits symptomatic of ASD. Psychotic spectrum disorder (PSD) would correspondingly result from an imbalance in favor of maternal and/or X-chromosome gene express...
متن کاملAn Unbiased Assessment of the Role of Imprinted Genes in an Intergenerational Model of Developmental Programming
Environmental factors during early life are critical for the later metabolic health of the individual and of future progeny. In our obesogenic environment, it is of great socioeconomic importance to investigate the mechanisms that contribute to the risk of metabolic ill health. Imprinted genes, a class of functionally mono-allelic genes critical for early growth and metabolic axis development, ...
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ژورنال
عنوان ژورنال: BMC Medical Genomics
سال: 2020
ISSN: 1755-8794
DOI: 10.1186/s12920-020-0693-2